منابع مشابه
A significant role for tumor necrosis factor in Nlrp3 inflammasomeopathies
Results Nearly all FCAS Il1bIl18-/-mice survived and grew normally until adulthood however, investigation of mice at > 6 months of age showed marked splenomegaly and elevated numbers of white blood cells as compared to FCAS Casp1 mice and non-mutant Il1bIl18-/-littermates, suggesting a caspase-1 dependent phenotype independent of IL-1b and IL-18. To examine other potential inflammatory mediator...
متن کاملEndometriosis Classification and The Role of Tumor Necrosis Factor-Alpha Polymorphisms as A Therapeutic Target
In the recent original research published on International Journal of Fertility and Sterility the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and endometriosis in 150 Iranian patients suffered this disease. The authors notably found a lower frequency of TNF-α -863C/A allele A among the affected patients in comparison with healthy women, although this difference...
متن کاملEvaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis
Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...
متن کاملRole of tumor necrosis factor-alpha in pathogenesis of recurrent aphthous stomatitis: A systematic review and meta-analysis
BACKGROUND AND AIM: Recurrent aphthous stomatitis (RAS) is a lesion of the oral cavity with an unknown etiology. Several studies have been performed on the role of tumor necrosis factor-alpha (TNF-α) in RAS. The main purpose of this paper was to review TNF-α level and its gene polymorphism in patients with RAS, the factors influencing the production of TNF-α, a...
متن کاملEssential Role of Tumor Necrosis Factor
To examine the hypothesis that tumor necrosis factor (TNF) a is an essential cytokine in carcinogenesis, we conducted two-stage carcinogenesis experiments with an initiator, 7,12-dimethylbenz(a)anthracene (DMBA), plus either of two tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol13-acetate (TPA), on the skin of TNF-a-deficient (TNF) mice. TNF mice treated with DMBA plus okadaic acid ...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2015
ISSN: 1546-0096
DOI: 10.1186/1546-0096-13-s1-o27